Special Issue: Novel targeted therapies
نویسندگان
چکیده
Kazuo Okamoto1,2,3) and Hiroshi Takayanagi *,1,2,3,4) 1)Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan 2)Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo, Japan 3)Japan Science and Technology Agency (JST), ERATO, Takayanagi Osteonetwork Project, Tokyo, Japan 4)Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Nedlands, WA, Australia
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Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma.
Osteosarcoma (OS) is a bone cancer mostly occurring in pediatric population. Current treatment regime of surgery and intensive chemotherapy could cure about 60%-75% patients with primary osteosarcoma, however only 15% to 30% can be cured when pulmonary metastasis or relapse has taken place. Hence, novel precise OS-targeting therapies are being developed with the hope of addressing this issue. T...
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Tumor-targeted therapies are playing growing roles in cancer research. The exploitation of these powerful therapeutic modalities largely depends on the discovery of tumor-targeting ligands. Phage display has proven a promising high throughput screening tool for the identification of novel specific peptides with high binding affinity to cancer cells. In the present study, we describe the use of ...
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